“The only vaccine that stops reinfection and protects against all virus strains”

TRANSMUNE, a successful vaccine in Poultry Industry

With 7.9 Bi doses sold during 2013 and 8.6 Bi doses for 2014,Transmune is the Broilers’ leader vaccine for the control of Gumboro disease, a widely prevalent and costly health problem of the Poultry Industry worldwide.

Since its international launching back in 2006 Transmune has already vaccinated more than 38 Billion broilers, a number that very few vaccines had achieved. This big presence has given to Cevaa real knowledge and impact in Gumboro vaccination.

Geographically, Transmune is present in more than 60 countries being Latin America and Asia Pacific zones the biggest markets where more than 75% of the sales are present. 

Brazil, China, Thailand, Philippines, Spain, Russia, Indonesia, Turkey, South Africa and Argentina are the 10 biggest countries for the product. 

Transmune is successfully used in Middle East as Lebanon, Bahrain and Kingdom of Saudi Arabia

So far,Transmune is not present (not licensed) in two big poultry countries: USA and India.

Gumboro Disease and a new approach for its Control

The Gumboro Disease which is produce by the Infectious Bursal Disease Virus (IBDV) is one of the most recognized, studied and problematic disease affecting the poultry producers worldwide, its control is classically done by a combination of vaccination and biosecurity procedures. Many times producers want to be protected against the negative consequences of the infection (mortality, immunodepression) but tend to forget the importance of preventing the challenge risk for the coming flocks, which will ensure the control in a long term approach; a correct Control strategy should consider both protection and prevention.

Recent scientific evidences initially found by Ceva’s researchers which are starting to be endorsedby the scientific community shown that some vaccines i.eTransmune, can give the both desired properties for protection and prevention making not only a big difference compared to the other vaccines available in the market but giving to the producers the ultimate solution for Gumboro Disease control that will lastly be translated in better performances and more profits.

The Gumboro Cycle

As the IBD virus is strongly resistant to environmental conditions and also to cleaning and disinfection procedures, it can survive for very long period of time. Normally all poultry houses are contaminated before the chicks are placed in. 

Once the chickens become susceptible to the infection, the virus replicates in its target organ (Bursa of Fabricius) being subsequently shed in exponential quantities to the poultry litter, putting the coming flocks on pressure cycle after cycle 

The scientific studies have proven that the most efficacious way to Stop this Cycle of reinfection is by blocking the infection of the Bursas of Fabricius, on this way the field Gumboro Virus (no matter the strain or how different it is) cannot replicate and consequently will not be shed. On time, the virus load in the litter will decrease putting less pressure to the coming flocks

In other words, by blocking the infection of the bursa the flocks will be protected and the challenge risk will be prevented.

Available Vaccines and the Gumboro Cycle

The superiority of Transmune in comparisson with other vaccines is summarized in the next two trials. 

The first one, carried out under field conditions in UK show how Transmune can be detected (means protection) in all the vaccinated birds (40 farms) whilest in the comparative group (40 farms) vaccinated with a Classical Intermediate Plus vaccine, only 80% of the population is protected, 20% remain completely susceptible.

This second graph show how Transmune completely protects against different strains of IBD Virus but in the comparative group vaccinated with a Recombinant HVT-VP2 vaccine the proteccion is partial, being very low against some strains. 

 *The competitor vaccine tested is actually the biggest competitor worldwide.

Conclusions “ Stop the Gumboro Cycle”

With Gumboro Immune-Complex vaccine ,Transmune, Ceva is offering a unique technical solution with 2 main targets:

•Protection of birds without interferences with Maternal Derived Antibodies and colonization of the Bursa

•Avoiding Field infection due to virus vaccine shedding in houses

With more than 20 billion vaccinated birds Transmune had fully proved its safety as well as its efficacy in the management of field challenges, hatchery vaccinations and return on investment for broiler managers.